Mannitol E965 supplier

Mannitol is used as an osmotic diuretic agent and a weak renal vasodilator.Mannitol is a sugar alcohol; that is, it is derived from a sugar by reduction, with a molecular weight of 182.17 g/mol.Mannitol is commonly formed via the hydrogenation of fructose, which is formed from either starch or sugar. The fructose is then hydrogenated over a nickel catalyst into mixture of isomers sorbitol and mannitol. Yield is typically 50%:50%, although slightly alkaline reaction conditions can slightly increase mannitol yields.

Mannitol is one of the most abundant energy and carbon storage molecules in nature, produced by a plethora of organisms, including bacteria, yeasts, fungi, algae, lichens, and many plants.A class of lactic acid bacteria,labeled heterofermentive because of their multiple fermentation pathways, convert either 3 fructose molecules or 2 fructose and 1 glucose molecule into 2 mannitol molecules, and one molecule each of lactic acid, acetic acid, and carbon dioxide. Feedstock syrups containing medium to large concentrations of fructose.

As stated above, mannitol is found in a wide variety of natural products, including almost all plants. This allows for direct extraction from natural products, rather than chemical or biological syntheses. In fact, in China, isolation from seaweeds is the most common form of mannitol production as a sweetener. Supercritical carbon dioxide extraction of olive leaves has been shown to require less solvent per grams of leaf than a traditional extraction.

Mannitol is used food additives in osmotherapy to reduce acutely raised intracranial pressure until more definitive treatment can be applied, e.g., after head trauma. It is also used to treat patients with oliguric renal failure. It is administered intravenously, and is filtered by the glomeruli of the kidney, but is incapable of being resorbed from the renal tubule, resulting in decreased water and Na+ reabsorption via its osmotic effect. Consequently, mannitol increases water and Na+ excretion, thereby decreasing extracellular fluid volume.

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