Rosemary extract antioxidant mechanism
As the active ingredient with a variety of antioxidants and a variety of anti-oxidation mechanism, resulting in a highly efficient and extensive rosemary antioxidant. Now widely recognized that the main mechanism of antioxidant rosemary can be in its singlet oxygen quenching, scavenging free radicals, cutting off a chain reaction of lipid auto-oxidation, chelate metal ions and organic acids and other synergies. Rosmarinic acid in the reduction of components such as phenolic hydroxyl, unsaturated double bond and acid, the presence of a single antioxidant, a synergistic effect when combined.
Han Hong magnitude established mouse model of exercise-induced oxidative damage, antioxidant rosemary extracts found in the endogenous diterpene phenolic compounds affect the oxidation system, is the material basis of antioxidant. Wang moderately active ingredients from rosemary structural analysis found that they have catechol (polyphenol antioxidants, the main active ingredient) structural skeleton, theoretically confirmed the oxidation resistance of these components and better stability. Del Bano MJ and other studies indicate, carnosic acid and carnosol in human lymphocytes before and after γ-ray treatment has a very strong anti-mutagenic activity, and before and after radiation therapy showed a different protection mechanisms. Singletary so that carnosol can effectively improve the rat liver glutathione S-transferase and quinone reductase activity; effective concerted DMBA-DNA adduct production, and inhibition of DMBA-induced tumors in rats . Rosemary diterpene phenol liver injury in mice has a good protective effect, and toxicity is very small, can become liver JiangMei drugs. Carnosol and rosemary phenol for breast cancer cell proliferation, showing strong inhibitory activity, the inhibitory activity of carnosol which has good selectivity, can be developed into a new breast cancer proliferation inhibitors.
Li Yueting and other studies indicate rosmarinic acid in 5 ~ 2 5mg / L concentration range can inhibit serum or lipopolysaccharide-stimulated rat mesangial cell food additives proliferation, in 1 ~ 2 5mg / L significantly inhibited the LPS-induced range mesangial cells IL - 1 β secretion. Shang Yanjun and other studies indicate, rosmarinic acid significantly inhibited uric acid production and superoxide ion-induced NBT color, is a competitive xanthine oxidase inhibitor. Zou noon so the rat in vivo, reported rosmarinic acid can inhibit venous thrombosis, inhibition of collagen-induced platelet aggregation, and promote the role of fibrinolytic activity. Peng-Fei Tu described in the article such as rosmarinic acid in the inhibition of thrombosis foreign and immune regulatory role. Peter Li and other summary of rosmarinic acid has anti-inflammatory activity, antioxidant activity, immunosuppressive activity, and others such as anti-thrombotic, anti-nephritis, anti-HIV, anti-depressants, anti-pneumonia, bacteria and other pharmacological effects.
As the active ingredient with a variety of antioxidants and a variety of anti-oxidation mechanism, resulting in a highly efficient and extensive rosemary antioxidant. Now widely recognized that the main mechanism of antioxidant rosemary can be in its singlet oxygen quenching, scavenging free radicals, cutting off a chain reaction of lipid auto-oxidation, chelate metal ions and organic acids and other synergies. Rosmarinic acid in the reduction of components such as phenolic hydroxyl, unsaturated double bond and acid, the presence of a single antioxidant, a synergistic effect when combined.
Han Hong magnitude established mouse model of exercise-induced oxidative damage, antioxidant rosemary extracts found in the endogenous diterpene phenolic compounds affect the oxidation system, is the material basis of antioxidant. Wang moderately active ingredients from rosemary structural analysis found that they have catechol (polyphenol antioxidants, the main active ingredient) structural skeleton, theoretically confirmed the oxidation resistance of these components and better stability. Del Bano MJ and other studies indicate, carnosic acid and carnosol in human lymphocytes before and after γ-ray treatment has a very strong anti-mutagenic activity, and before and after radiation therapy showed a different protection mechanisms. Singletary so that carnosol can effectively improve the rat liver glutathione S-transferase and quinone reductase activity; effective concerted DMBA-DNA adduct production, and inhibition of DMBA-induced tumors in rats . Rosemary diterpene phenol liver injury in mice has a good protective effect, and toxicity is very small, can become liver JiangMei drugs. Carnosol and rosemary phenol for breast cancer cell proliferation, showing strong inhibitory activity, the inhibitory activity of carnosol which has good selectivity, can be developed into a new breast cancer proliferation inhibitors.
Li Yueting and other studies indicate rosmarinic acid in 5 ~ 2 5mg / L concentration range can inhibit serum or lipopolysaccharide-stimulated rat mesangial cell food additives proliferation, in 1 ~ 2 5mg / L significantly inhibited the LPS-induced range mesangial cells IL - 1 β secretion. Shang Yanjun and other studies indicate, rosmarinic acid significantly inhibited uric acid production and superoxide ion-induced NBT color, is a competitive xanthine oxidase inhibitor. Zou noon so the rat in vivo, reported rosmarinic acid can inhibit venous thrombosis, inhibition of collagen-induced platelet aggregation, and promote the role of fibrinolytic activity. Peng-Fei Tu described in the article such as rosmarinic acid in the inhibition of thrombosis foreign and immune regulatory role. Peter Li and other summary of rosmarinic acid has anti-inflammatory activity, antioxidant activity, immunosuppressive activity, and others such as anti-thrombotic, anti-nephritis, anti-HIV, anti-depressants, anti-pneumonia, bacteria and other pharmacological effects.
