Grape seed extract of Foodchem

While grape seed extract has shown activity in a number of laboratory cancer cell lines, including skin, breast, colon, lung, stomach and prostate cancers, no one had tested the extract in hematological cancers nor had the precise mechanism for activity been revealed. Given that epidemiological evidence shows that eating vegetables and fruits helps prevent cancer development, Shi and his colleagues have been studying chemicals known as proanthocyanidins in fruits that contribute to this effect.
"This is a natural compound that appears to have relatively important properties," Shi said. Grape seed extract is a Dietary Supplement. Each capsule of this grape seed extract supplement provides 95 mg of potent polyphenols. Grape seed extracts have compounds called procyanidolic oligomers (PCOs). Other sources of PCOs are berries, green and black teas, and red wine. Grape seed extract is rich in procyanidins, a special class of water-soluble bioflavonoids.
They double checked their finding by showing that the grape seed extract didn't work when used with an agent that blocked JNK: this was a pharmacologic approach. He and colleagues then examined the underlying mechanisms by which the grape seed extract caused the leukemia cells to commit suicide. They also discovered that the extract did not affect normal cells but they weren't able to determine why.
Aside from being powerful antioxidants, OPCs inhibit a number of enzymes that degrade connective tissue such as elastase, collagenase, and hyaluronidase. Grape seed extract as a food additives, in contrast,is believed to remain available in the body for as long as three days. Grape seed extract contains healthy ingredients including protein, lipids, carbohydrates and polyphenols.

Other food additives: L-Tyrosine            green tea extract