The vitamin was not originally given this name, however, but was referred to as "antidermatitis factor." Transamination: transaminase enzymes needed to break down amino acids are dependent on the presence of pyridoxal phosphate. The proper activity of these enzymes are crucial for the process of moving amine groups from one amino acid to another.
Vitamin B6 also plays a role in gluconeogenesis. Pyridoxal phosphate can catalyze transamination reactions that are essential for the providing amino acids as a substrate for gluconeogenesis. Also, vitamin B6 is a required coenzyme of glycogen phosphorylase. In addition, the breakdown of sphingolipids is also dependent on vitamin B6 since S1P lyase, the enzyme responsible for breaking down sphingosine-1-phosphate, is also PLP dependent.
Vitamin B6 in coenzyme forms performs a wide variety of functions in the body and is extremely versatile, with involvement in more than 100 enzyme reactions, mostly concerned with protein metabolism. The human body absorbs vitamin B6 as a food additive in the jejunum. Phosphorylated forms of the vitamin are dephosphorylated, and the pool of free vitamin B6 is absorbed by passive diffusion.
Intake recommendations for vitamin B6 and other nutrients are provided in the Dietary Reference Intakes. Vitamin B6 is found in a wide variety of foods. About 75% of vitamin B6 from a mixed diet is bioavailable.
Others: Green tea extract Alpha-lipoic acid
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